Natural products have long been a major source of new medicines. About 50% of the drugs introduced to the market in the last 20 years trace their origin to compounds derived from nature. A similar impact has been experienced in animal health and agrochemical discovery.

BioFocus DPI offers the latest advances in discovery technologies to discover promising hit and lead molecules from fungal and bacterial sources of natural products. Natural product-based compounds offer chemical structures unavailable in synthetic chemistry collections. The compounds in our natural products collection display:
• Potent pharmacological activities over a broad range of biological targets
• High chemical and functional diversity
• Desirable physicochemical properties

BioFocus DPI has an advanced, comprehensive suite of technologies that greatly simplify natural product-based drug discovery. Integrated activities and technologies include:
• Access to ~140,000 highly diverse pre-purified natural compound sub-fractions
• Over 700 pure natural compounds

• Preparation and screening of focused libraries based on natural product scaffolds
• High-throughput screening against a broad range of target classes
• Large-scale isolation of active compounds
• Rapid structure elucidation
• Chemical synthesis and derivatization
• Lead optimization including profiling studies

Subfraction library
BioFocus DPI has an exclusive collection of over 45,000 rare actinomycetes and 8,000 fungi. Using a proprietary fermentation process, excellent expression of secondary metabolites is obtained from the strains of our collection. We then apply a unique subfractionation process to obtain pre-purified natural compound samples that are suitable for (ultra)high-throughput screening. Approximately 140,000 subfractions (each containing approximately 10 to 15 compounds) are currently available for screening.  Please follow this link to learn more about our Subfraction Screening Projects

Natural compounds

BioFocus DPI offers a collection of natural compounds and derivatives covering a broad range of biological activities.  The collection includes compounds acting on specific target classes, such as inhibitors of HSP90, kinases and proton-ATPases; natural compounds interacting with specific pathways, such as apoptosis, angiogenesis and immunosuppression; as well as compounds with cytotoxic or antimicrobial activities. 

Please follow this link to download our latest Natural Product Catalog

In addition, BioFocus DPI offers a collection of 245 pure natural compounds which are, to the best of our knowledge, not commercially available elsewhere.

Please follow this link to access our Natural Compound Library NPL01

Our NatFocus Libraries are small focused compound collections based on natural product scaffolds with attractive biological activity, physicochemical properties and structural features.

Please follow this link to access our NatFocus Libraries 

Contact us to learn more about our natural product libraries.